Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalyst† †Electronic supplementary information (ESI) available: General procedures, materials, and instrumentation; synthesis, characterization and relevant spectra/charts; procedures and results for optimization and additional experiments. See DOI: 10.1039/c6sc03849b Click here for additional data file.

Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel-Crafts reactions with a chiral bifunctional heterogeneous catalyst.

A new class of chiral bifunctional heterogeneous materials composed of Au/Pd nanoparticles and chiral phosphoric acids as active orthogonal catalysts was prepared by utilizing a facile pseudo-suspension co-polymerization method. It was found that this heterogeneous catalyst was capable of facilitating the sequential aerobic oxidation-asymmetric intramolecular aza-Friedel-Crafts reaction between...

Synergistic cascade catalysis by metal nanoparticles and Lewis acids in hydrogen autotransfer† †Electronic supplementary information (ESI) available: General procedures, materials, and instrumentation; synthesis, characterization and relevant spectra/charts; procedures and results for optimization and additional experiments. See DOI: 10.1039/c4sc03627a Click here for additional data file.

A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterization data for all new compounds. CCDC 1512973–1512975. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05472b Click here for additional data file. Click here for additional data file.

Identifying lead hits in catalyst discovery by screening and deconvoluting complex mixtures of catalyst components† †Electronic supplementary information (ESI) available: Experimental procedures and spectral data. See DOI: 10.1039/c5sc00268k Click here for additional data file.

A reaction-economic combinatorial strategy is described for lead hit identification in catalyst discovery efforts directed towards a specific transformation. Complex mixtures of rationally chosen precatalysts and ligands are screened against various reaction parameters to identify lead conditions in a small number of reactions. Iterative deconvolution of the resulting hits identifies which comp...

Expedient synthesis of the heneicosasaccharyl mannose capped arabinomannan of the Mycobacterium tuberculosis cellular envelope by glycosyl carbonate donors† †Electronic supplementary information (ESI) available: Experimental procedures, compound characterization data and spectral charts. See DOI: 10.1039/c6sc04866h Click here for additional data file.